“What’s interesting is that we saw this inverse relationship between decreased slow-wave sleep and more tau protein in people who were either cognitively normal or very mildly impaired, meaning that reduced slow-wave activity may be a marker for the transition between normal and impaired,” said first author Brendan Lucey, MD, an assistant professor of neurology and director of the Washington University Sleep Medicine Center. 9 in Science Translational Medicine, suggest that poor-quality sleep in later life could be a red flag for deteriorating brain health.ĭoctors may soon be able to predict, prevent Alzheimer’s disease Elevated tau is a sign of Alzheimer’s disease and has been linked to brain damage and cognitive decline. They found that older people who have less slow-wave sleep – the deep sleep you need to consolidate memories and wake up feeling refreshed – have higher levels of the brain protein tau. Louis may have uncovered part of the explanation. Now, researchers at Washington University School of Medicine in St. But how and why restless nights are linked to Alzheimer’s disease is not fully understood. People with the disease tend to wake up tired, and their nights become even less refreshing as memory loss and other symptoms worsen. Poor sleep is a hallmark of Alzheimer’s disease. Louis has found that decreased deep sleep is associated with early signs of Alzheimer’s disease. A new study from Washington University School of Medicine in St. This computer-generated image maps the areas where the link is strongest, in shades of red and orange. Reduced amounts of slow brain waves – the kind that occur in deep, refreshing sleep – are associated with high levels of the toxic brain protein tau. Toxic brain protein tau elevated in older people who sleep poorly News Release Decreased deep sleep linked to early signs of Alzheimer’s disease
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